Cover Image

Identification and regulation of the long non-coding RNA Heat2 in heart failure

Aims - Circulating immune cells have a significant impact on progression and outcome of heart failure. Long non-coding RNAs (lncRNAs) comprise novel epigenetic regulators which control cardiovascular diseases and inflammatory disorders. We aimed to identify lncRNAs regulated in circulating immune ce...

Full description

Saved in:
Bibliographic Details
Main Authors: Boeckel, Jes-Niels (Author) , Katus, Hugo (Author) , Haas, Jan (Author) , Kayvanpour, Elham (Author) , Grabe, Niels (Author) , Dieterich, Christoph (Author) , Leuschner, Florian (Author) , Meder, Benjamin (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Journal of molecular and cellular cardiology
Year: 2018, Volume: 126, Pages: 13-22
ISSN:1095-8584
DOI:10.1016/j.yjmcc.2018.11.004
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.yjmcc.2018.11.004
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0022282818303869
Get full text
Author Notes:Jes-Niels Boeckel, Maya F. Perret, Simone F. Glaser, Timon Seeger, Andreas W. Heumüller, Wei Chen, David John, Karoline E. Kokot, Hugo A. Katus, Jan Haas, Maximilian K. Lackner, Elham Kayvanpour, Niels Grabe, Christoph Dieterich, Stephan von Haehling, Nicole Ebner, Sabine Hünecke, Florian Leuschner, Stephan Fichtlscherer, Benjamin Meder, Andreas M. Zeiher, Stefanie Dimmeler, Till Keller
Description
Summary:Aims - Circulating immune cells have a significant impact on progression and outcome of heart failure. Long non-coding RNAs (lncRNAs) comprise novel epigenetic regulators which control cardiovascular diseases and inflammatory disorders. We aimed to identify lncRNAs regulated in circulating immune cells of the blood of heart failure patients. - Methods and results - Next-generation sequencing revealed 110 potentially non-coding RNA transcripts differentially expressed in peripheral blood mononuclear cells of heart failure patients with reduced ejection fraction. The up-regulated lncRNA Heat2 was further functionally characterized. Heat2 expression was detected in whole blood, PBMNCs, eosinophil and basophil granulocytes. Heat2 regulates cell division, invasion, transmigration and immune cell adhesion on endothelial cells. - Conclusion - Heat2 is an immune cell enriched lncRNA that is elevated in the blood of heart failure patients and controls cellular functions.
Item Description:Available online 13 November 2018
Gesehen am 10.07.2019
Physical Description:Online Resource
ISSN:1095-8584
DOI:10.1016/j.yjmcc.2018.11.004

Similar Items