New opportunities for allergen immunotherapy using synthetic peptide immuno-regulatory epitopes (SPIREs)
Introduction: Allergen immunotherapy (AIT) reduces allergic rhinoconjunctivitis (ARC) symptoms, but long-term efficacy requires treatment for 3-5 years. Synthetic peptide immuno-regulatory epitopes, a new class of AIT, are allergen peptides with a shorter, more convenient treatment regimen that coul...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 Jun 2016
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| In: |
Expert review of clinical immunology
Year: 2016, Volume: 12, Issue: 10, Pages: 1123-1135 |
| ISSN: | 1744-8409 |
| DOI: | 10.1080/1744666X.2016.1189825 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1080/1744666X.2016.1189825
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| Author Notes: | Ludger Klimek, Oliver Pfaar, Margitta Worm |
| Summary: | Introduction: Allergen immunotherapy (AIT) reduces allergic rhinoconjunctivitis (ARC) symptoms, but long-term efficacy requires treatment for 3-5 years. Synthetic peptide immuno-regulatory epitopes, a new class of AIT, are allergen peptides with a shorter, more convenient treatment regimen that could potentially have benefits on adherence and outcomes.Areas covered: Phase 2 trials of therapies derived from cat, house dust mite, grass, and ragweed allergen peptides demonstrated significant reduction in ARC symptoms after short-course treatment; improvement was sustained for 18-24 months posttreatment. We conducted a PubMed literature search for clinical publications using the search terms AIT; allergen peptides; ARC; cat, grass, house dust mite, and ragweed allergy; SCIT; SLIT; and synthetic peptides.Expert commentary: Long-term disease modification is a realistic goal of AIT. The inconvenience of conventional AIT regimens negatively impacts long-term persistence and, thus, efficacy. In comparison, SPIREs have a more convenient treatment regimen that could potentially have benefits on adherence and outcomes. |
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| Item Description: | Gesehen am 10.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1744-8409 |
| DOI: | 10.1080/1744666X.2016.1189825 |