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Advances in multidisciplinary therapy for meningiomas

Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that...

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Main Authors: Brastianos, Priscilla K. (Author) , Galanis, Evanthia (Author) , Butowski, Nicholas (Author) , Chan, Jason W. (Author) , Dunn, Ian F. (Author) , Goldbrunner, Roland (Author) , Herold-Mende, Christel (Author) , Ippen, Franziska M. (Author) , Mawrin, Christian (Author) , McDermott, Michael W. (Author) , Sloan, Andrew (Author) , Snyder, James (Author) , Tabatabai, Ghazaleh (Author) , Tatagiba, Marcos (Author) , Tonn, Jörg-Christian (Author) , Wen, Patrick Y. (Author) , Aldape, Kenneth (Author) , Nassiri, Farshad (Author) , Zadeh, Gelareh (Author) , Jenkinson, Michael D. (Author) , Raleigh, David R. (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2019
In: Neuro-Oncology
Year: 2019, Volume: 21, Pages: 18-31
ISSN:1523-5866
DOI:10.1093/neuonc/noy136
Online Access:Verlag, Volltext: https://doi.org/10.1093/neuonc/noy136
Verlag, Volltext: https://academic.oup.com/neuro-oncology/article/21/Supplement_1/i18/5289364
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Author Notes:Priscilla K. Brastianos, Evanthia Galanis, Nicholas Butowski, Jason W. Chan, Ian F. Dunn, Roland Goldbrunner, Christel Herold-Mende, Franziska M. Ippen, Christian Mawrin, Michael W. McDermott, Andrew Sloan, James Snyder, Ghazaleh Tabatabai, Marcos Tatagiba, Joerg C. Tonn, Patrick Y. Wen, Kenneth Aldape, Farshad Nassiri, Gelareh Zadeh, Michael D. Jenkinson, David R. Raleigh, and the International Consortium on Meningiomas
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Summary:Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.
Item Description:Gesehen am 11.07.2019
Physical Description:Online Resource
ISSN:1523-5866
DOI:10.1093/neuonc/noy136

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