DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development
Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the DNA methylome, its fu...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 April 2019
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| In: |
Acta Neuropathologica Communications
Year: 2019, Volume: 7, Pages: 1-18 |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-019-0704-8 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s40478-019-0704-8
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| Author Notes: | H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D.T.W. Jones, S.M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Tatagiba, U. Herrlinger, H. Vatter, J. Matschke, M. Westphal, D. Krex, G. Schackert, J.C. Tonn, U. Schlegel, H.-J. Steiger, W. Wick, R. Weber, M. Weller, and M. Loeffler |
| Summary: | Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the DNA methylome, its function in tumor biology, coupling with the transcriptome and tumor microenvironment and its possible impact for tumor development. |
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| Item Description: | Gesehen am 18.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-019-0704-8 |