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Long intergenic noncoding RNA 299 methylation in peripheral blood is a biomarker for triple-negative breast cancer

Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case–control pairs (discovery set) and...

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Main Authors: Lorenzo Bermejo, Justo (Author) , Hamann, Ute (Author) , Hoheisel, Jörg D. (Author) , Garcia Mesa, Karen (Author) , González Silos, Rosa (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Epigenomics
Year: 2019, Volume: 11, Issue: 1, Pages: 81-93
ISSN:1750-192X
DOI:10.2217/epi-2018-0121
Online Access:Verlag, Volltext: https://doi.org/10.2217/epi-2018-0121
Verlag, Volltext: https://www.futuremedicine.com/doi/10.2217/epi-2018-0121
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Author Notes:Justo L Bermejo, Guanmengqian Huang, Mehdi Manoochehri, Karen G Mesa, Matthias Schick, Rosa G Silos, Yon-Dschun Ko, Thomas Brüning, Hiltrud Brauch, Wing-Yee Lo, Jörg D Hoheisel & Ute Hamann
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Summary:Aim: To identify DNA methylation biomarkers in peripheral blood samples from triple-negative breast cancer (TNBC) patients. Materials & methods: We conducted an epigenome-wide association study (EWAS): the most promising markers were identified in 233 TNBC case–control pairs (discovery set) and subsequently validated in an independent validation set (57 TNBC patients and 124 controls). Results: cg06588802 (LINC00299/ID2) showed a higher methylation in TNBC patients compared with controls (discovery set: 3% increase, p-value = 0.0009; validation set: 2% increase, p-value = 0.01). Consistent results at four neighboring methylation probes and the strong negative correlation (rho = -0.93) with LINC00299 expression add plausibility to this result. Conclusion: Hypermethylation of LINC00299 in peripheral blood may constitute a useful circulating biomarker for TNBC.
Item Description:Published online 13 September 2018
Gesehen am 19.07.2019
Physical Description:Online Resource
ISSN:1750-192X
DOI:10.2217/epi-2018-0121

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