Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine
In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epitopes. Unfortunately, such T-cell responses are frequently dominated by responses to non-prot...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 May 2019
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| In: |
Journal of translational medicine
Year: 2019, Volume: 17, Pages: 1-18 |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/s12967-019-1924-1 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s12967-019-1924-1
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| Author Notes: | Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch, Peter Johannes Holst |
| Summary: | In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epitopes. Unfortunately, such T-cell responses are frequently dominated by responses to non-protective, variable epitopes. In this study we attempt to combine three independent approaches, each developed to prevent immunodominance of non-protective epitopes. These approaches were (1) vaccines consisting exclusively of putatively protective p24 Gag highly conserved elements (CEs), (2) vaccines using solely subdominant antigens which were acutely protective in a recent NHP trial, and (3) virus-encoded virus-like particle vaccines (virus-like vaccines/VLVs) using heterologous Env and Gag sequences to enable selection of broadly cross-reactive responses and to avoid immunodominance of non-conserved sequences in prime-boost regimens as previously observed. |
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| Item Description: | Gesehen am 22.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1479-5876 |
| DOI: | 10.1186/s12967-019-1924-1 |