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Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-fr...

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Main Authors: Imle, Andrea (Author) , Kumberger, Peter (Author) , Schnellbächer, Nikolas David (Author) , Carrillo-Bustamante, Paola (Author) , Aleš, Janez (Author) , Ritter, Christian (Author) , Godinez, William J. (Author) , Müller, Barbara (Author) , Rohr, Karl (Author) , Hamprecht, Fred (Author) , Schwarz, Ulrich S. (Author) , Graw, Frederik (Author) , Fackler, Oliver Till (Author)
Format: Article (Journal)
Language:English
Published: 13 May 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-09879-3
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-019-09879-3
Verlag, Volltext: https://www.nature.com/articles/s41467-019-09879-3
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Author Notes:Andrea Imle, Peter Kumberger, Nikolas D. Schnellbächer, Jana Fehr, Paola Carrillo-Bustamante, Janez Ales, Philip Schmidt, Christian Ritter, William J. Godinez, Barbara Müller, Karl Rohr, Fred A. Hamprecht, Ulrich S. Schwarz, Frederik Graw & Oliver T. Fackler
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Summary:Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different collagen matrices restrict infection by cell-free virions.
Item Description:Gesehen am 22.07.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-09879-3

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