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The optimal intestinal segment length for experimental size-mismatched intestinal transplantation: Defining the maximum length with the lowest blood flow needs in a porcine model

Transplanted Intestinal Segments (IS) must match the perfusion capacities of the recipient. This can be challenging during a size-mismatched SBTX. In this study, we defined the maximum IS length with lowest blood flow needs in a porcine model by evaluating the physiological perfusion rates of differ...

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Bibliographic Details
Main Authors: Frongia, Giovanni (Author) , Majlesara, Ali (Author) , Golriz, Mohammad (Author) , Günther, Patrick (Author) , Mehrabi, Arianeb (Author)
Format: Article (Journal)
Language:English
Published: 18 January 2018
In: Pediatric transplantation
Year: 2018, Volume: 22, Issue: 2, Pages: 13135
ISSN:1399-3046
DOI:10.1111/petr.13135
Online Access:Verlag, Volltext: https://doi.org/10.1111/petr.13135
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/petr.13135
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Author Notes:Giovanni Frongia, Ali Majlesara, Arash Saffari, Golnaz Emami, Mohammad Golriz, Patrick Günther, Arianeb Mehrabi
Description
Summary:Transplanted Intestinal Segments (IS) must match the perfusion capacities of the recipient. This can be challenging during a size-mismatched SBTX. In this study, we defined the maximum IS length with lowest blood flow needs in a porcine model by evaluating the physiological perfusion rates of different IS lengths. Blood flow in the SMA, aorta segment four, and general circulatory parameters were monitored before and after sequential intestinal resection. IS lengths of 30 cm, 60 cm, 120 cm, and 300 cm (n = 8 each) were compared. The IS blood flow requirements increased with IS length (30 cm: 19.5 ± 3.4 mL/min; 60 cm: 16.9 ± 6.7 mL/min; 120 cm: 34.9 ± 8.5 mL/min; 300 cm: 62.9 ± 11.6 mL/min). Absolute IS blood flow (P = .004), percentage IS blood flow uptake from the SMA (P = .001), and percentage IS blood flow uptake from the aorta (P = .005) increased significantly between 60 cm and 120 cm. We concluded that 60 cm was the maximum IS length before blood flow demands significantly increased in a porcine model.
Item Description:Gesehen am 29.07.2019
Physical Description:Online Resource
ISSN:1399-3046
DOI:10.1111/petr.13135

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