Regulatory T cells sense effector T-cell activation through synchronized JunB expression
To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is induced in Teffs upon T-cell recep...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 April 2019
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| In: |
FEBS letters
Year: 2019, Volume: 593, Issue: 10, Pages: 1020-1029 |
| ISSN: | 1873-3468 |
| DOI: | 10.1002/1873-3468.13393 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1002/1873-3468.13393 Verlag, Volltext: https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13393 
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| Author Notes: | Jingxia Wu, Sicong Ma, Agnes Hotz-Wagenblatt, Peter Angel, Kerstin Mohr, Tilo Schlimbach, Michael Schmitt, Guoliang Cui |
| Summary: | To maintain immune tolerance, effector T-cell (Teff) responses must be checked by the regulatory T cells (Tregs) in time. It remains incompletely understood how Tregs sense real-time Teff activation. Here, we report that the AP-1 transcription factor JunB, which is induced in Teffs upon T-cell receptor (TCR) activation, is also increased in Tregs by TCR stimuli. Treg-specific deletion of Junb impairs Treg identity, causes uncontrolled inflammatory cytokine production by Teffs and leads to the T-box transcription factor T-bet-dependent spontaneous inflammation. Furthermore, JunB deficiency in Tregs unleashes antitumor Teff responses in a mouse model of melanoma. We conclude that JunB alarms Tregs of the emerging Teff activation and synchronizes immune regulation with the immune reaction in autoimmunity and cancer. |
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| Item Description: | Gesehen am 30.07.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3468 |
| DOI: | 10.1002/1873-3468.13393 |