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Low frequency of mismatch repair deficiency in gallbladder cancer

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DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as microsatellite instability (MSI). MSI tumors have a distinct clinical behavior and commonly res...

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Main Authors: Goeppert, Benjamin (Author) , Rössler, Stephanie (Author) , Renner, Marcus (Author) , Löffler, Moritz (Author) , Singer, Stephan (Author) , Albrecht, Thomas (Author) , Mehrabi, Arianeb (Author) , Vogel, Monika Nadja (Author) , Pathil-Warth, Anita (Author) , Busch, Elena (Author) , Köhler, Bruno Christian (Author) , Springfeld, Christoph (Author) , Rupp, Christian (Author) , Weiss, Karl Heinz (Author) , Schirmacher, Peter (Author) , Knebel Doeberitz, Magnus von (Author) , Kloor, Matthias (Author)
Format: Article (Journal)
Language:English
Published: 08 May 2019
In: Diagnostic pathology
Year: 2019, Volume: 14, Pages: 1-6
ISSN:1746-1596
DOI:10.1186/s13000-019-0813-5
Online Access:Verlag, Volltext: https://doi.org/10.1186/s13000-019-0813-5
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Author Notes:Benjamin Goeppert, Stephanie Roessler, Marcus Renner, Moritz Loeffler, Stephan Singer, Melina Rausch, Thomas Albrecht, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Elena Czink, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Peter Schirmacher, Magnus von Knebel Doeberitz and Matthias Kloor
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Summary:DNA mismatch repair (MMR) deficiency is a major pathway of genomic instability in cancer. It leads to the accumulation of numerous mutations predominantly at microsatellite sequences, a phenotype known as microsatellite instability (MSI). MSI tumors have a distinct clinical behavior and commonly respond well to immune checkpoint blockade, irrespective of their origin. Data about the prevalence of MSI among gallbladder cancer (GBC) have been conflicting. We here analyzed a well-characterized cohort of 69 Western-world GBCs.
Item Description:Gesehen am 05.08.2019
Physical Description:Online Resource
ISSN:1746-1596
DOI:10.1186/s13000-019-0813-5

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