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Dual-contrast pCASL using simultaneous gradient-echo/spin-echo multiband EPI

A 2D gradient-echo EPI is commonly employed for arterial spin labeling (ASL) readout to achieve fast whole brain coverage measurements. However, such a readout suffers from susceptibility artifacts induced by magnetic field inhomogeneities. To reduce these susceptibility effects, single-shot spin-ec...

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Main Authors: Zhang, Ke (Author) , Sturm, Volker Jörg Friedrich (Author) , Buschle, Lukas R. (Author) , Hahn, Artur (Author) , Bendszus, Martin (Author) , Heiland, Sabine (Author) , Schlemmer, Heinz-Peter (Author) , Ziener, Christian H. (Author) , Kurz, Felix T. (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Magnetic resonance imaging
Year: 2018, Volume: 57, Pages: 359-367
ISSN:1873-5894
DOI:10.1016/j.mri.2018.11.018
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.mri.2018.11.018
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0730725X18304430
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Author Notes:Ke Zhang, Volker J. Sturm, Lukas R. Buschle, Artur Hahn, Seong Dae Yun, N. Jon Shah, Martin Bendszus, Sabine Heiland, Heinz-Peter Schlemmer, Christian H. Ziener, Felix T. Kurz
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Summary:A 2D gradient-echo EPI is commonly employed for arterial spin labeling (ASL) readout to achieve fast whole brain coverage measurements. However, such a readout suffers from susceptibility artifacts induced by magnetic field inhomogeneities. To reduce these susceptibility effects, single-shot spin-echo EPI was proposed to be used for acquisitions in continuous ASL (CASL). To minimize functional and physiological variations, a gradient-echo (GE)/spin-echo (SE) dual-echo EPI readout of the CASL sequence is needed for a comparison between GE- and SE-based determination of cerebral blood flow (CBF). In this study, we employed a simultaneous GE/SE multiband EPI as the readout of a pseudo-CASL (pCASL) sequence. Motor cortex activations derived from a finger-tapping task and functional networks from resting state fMRI were compared for both GE and SE contrasts. Direct comparison of SE and GE contrasts revealed that GE ASL provides an improved sensitivity of functional activity in finger-tapping and in resting-state imaging. SE ASL, on the other hand, suffered less from susceptibility artifacts induced by magnetic field inhomogeneities and pulsatile flow artifacts.
Item Description:Available online 27 November 2018
Gesehen am 30.03.2020
Physical Description:Online Resource
ISSN:1873-5894
DOI:10.1016/j.mri.2018.11.018

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