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Multiplexed orthogonal genome editing and transcriptional activation by Cas12a

The length of the guide RNA for Cas12a-VPR determines whether a target gene is edited or activated and allows for multiplexed, combinatorial gene modifications.

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Bibliographic Details
Main Authors: Breinig, Marco (Author) , Schweitzer, Anabel (Author) , Herianto, Anna (Author) , Revia, Steffie (Author) , Schäfer, Lisa (Author) , Wendler, Lena (Author) , Cobos, Ana (Author) , Tschaharganeh, Darjus-Felix (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Nature methods
Year: 2018, Volume: 16, Issue: 1, Pages: 51-54
ISSN:1548-7105
DOI:10.1038/s41592-018-0262-1
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41592-018-0262-1
Verlag, Volltext: https://www.nature.com/articles/s41592-018-0262-1
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Author Notes:Marco Breinig, Anabel Y. Schweitzer, Anna M. Herianto, Steffie Revia, Lisa Schaefer, Lena Wendler, Ana Cobos Galvez, Darjus F. Tschaharganeh
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Summary:The length of the guide RNA for Cas12a-VPR determines whether a target gene is edited or activated and allows for multiplexed, combinatorial gene modifications.
Item Description:Published: 17 December 2018
Gesehen am 07.08.2019
Physical Description:Online Resource
ISSN:1548-7105
DOI:10.1038/s41592-018-0262-1

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