Rare encounters: primary pineal malignant melanoma with lepto-meningeal spread. Case report and literature review on management challenges and outcomes
Primary melanomas of the central nervous system (CNS) are unusual, accounting for 0.07% of brain tumours, and those in the pineal region are extremely difficult to diagnose preoperatively [1]. Melanocytes are typical of tissues such as the skin and mucosae, but they can be found also in other organs...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 06, 2019
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| In: |
Journal of clinical neuroscience
Year: 2019, Volume: 65, Pages: 161-165 |
| ISSN: | 1532-2653 |
| DOI: | 10.1016/j.jocn.2019.03.029 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jocn.2019.03.029 Verlag, Volltext: https://www.jocn-journal.com/article/S0967-5868(19)30240-1/abstract 
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| Author Notes: | Farouk Hajhouji, Mario Ganau, Cebula Helene, Antonio Romano, Arthur Gubian, Francois Proust, Salvatore Chibbaro |
| Summary: | Primary melanomas of the central nervous system (CNS) are unusual, accounting for 0.07% of brain tumours, and those in the pineal region are extremely difficult to diagnose preoperatively [1]. Melanocytes are typical of tissues such as the skin and mucosae, but they can be found also in other organs: the uvea for instance, or the brain parenchyma and leptomeninges. Only 1% of melanomas have a primary intracranial localization, of note Gibson and Burrows [2] were the first to identify melanin-producing cells within the CNS and to propose that those cells were capable of malignant transformation. |
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| Item Description: | Gesehen am 07.08.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1532-2653 |
| DOI: | 10.1016/j.jocn.2019.03.029 |