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Liver and cholestatic parameters as prognostic biomarkers of in-hospital MACE in patients with STEMI

Background Liver and cholestatic parameters are increased in ST-segment elevation myocardial infarction (STEMI). The aim of the present study was to evaluate the prognostic value of these parameters to predict in-hospital major adverse cardiac events (MACE) in patients after STEMI. Materials and met...

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Main Authors: Huseynov, Aydin (Author) , Baumann, Stefan (Author) , Becher, Tobias (Author) , Köpp, Johanna (Author) , Lang, Siegfried (Author) , Jabbour, Claude (Author) , Behnes, Michael (Author) , Borggrefe, Martin (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: August 2016
In: European journal of clinical investigation
Year: 2016, Volume: 46, Issue: 8, Pages: 721-729
ISSN:1365-2362
DOI:10.1111/eci.12655
Online Access:Verlag, Volltext: https://doi.org/10.1111/eci.12655
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12655
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Author Notes:Aydin Huseynov, Stefan Baumann, Tobias Becher, Johanna Koepp, Siegfried Lang, Claude Jabbour, Michael Behnes, Martin Borggrefe and Ibrahim Akin
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Summary:Background Liver and cholestatic parameters are increased in ST-segment elevation myocardial infarction (STEMI). The aim of the present study was to evaluate the prognostic value of these parameters to predict in-hospital major adverse cardiac events (MACE) in patients after STEMI. Materials and methods Blood samples of patients with STEMI, who underwent percutaneous coronary intervention (PCI) and stent implantation, were retrospectively analysed and correlated with in-hospital events. Results The study population consisted of 847 consecutive patients (62·4 ± 13·43 years; 73·8% male). The total in-hospital MACE rate was 9·8%, driven by death of any cause (8·4%). The Mann-Whitney U-test revealed that liver and cholestatic parameters (alanine transaminase P < 0·0001, aspartate transaminase P < 0·0001, alkaline phosphatase (AP) P < 0·0001, gamma-glutamyl transferase P = 0·0006 and total bilirubin P = 0·0023) were significantly higher in the MACE group. Further logistic regression analyses confirmed the correlation between MACE and all five laboratory markers, even after adjustment for age and heart enzymes. Logistic regression model revealed AP to be the best predictor for worth outcome (OR 1·0188; 95% CI 1·0118-1·0258; P < 0·0001). Conclusion Liver and cholestatic parameters are elevated in patients after STEMI. Increased AP is associated with in-hospital event rates.
Item Description:Gesehen am 08.08.2019
Physical Description:Online Resource
ISSN:1365-2362
DOI:10.1111/eci.12655

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