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Occupations and the risk of head and neck cancer: a pooled analysis of the International Head and Neck Cancer Epidemiology (INHANCE) consortium

OBJECTIVE: To investigate the associations between head and neck cancer (HNC) risk and occupations. - METHODS: We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was...

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Bibliographic Details
Main Authors: Khetan, Prerna (Author) , Ramroth, Heribert (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: May 2019
In: Journal of occupational and environmental medicine
Year: 2019, Volume: 61, Issue: 5, Pages: 397-404
ISSN:1536-5948
DOI:10.1097/JOM.0000000000001563
Online Access:Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1097/JOM.0000000000001563
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Author Notes:Prerna Khetan, Paolo Boffetta, Daniele Luce, Isabelle Stucker, Maria Paula Curado, Ana Menezes, Victor Wunsch-Filho, Wolfgang Ahrens, Pagona Lagiou, Diego Serraino, Lorenzo Richiardi, Kristina Kjaerheim, David Conway, Peter Thomson, Joshua Muscat, Dana Mates, Heribert Ramroth, Gwenn Menvielle, Thomas L. Vaughan, Hermann Brenner, Yuan-Chin Amy Lee, Carlo La Vecchia, Mia Hashibe, Dana Hashim
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Summary:OBJECTIVE: To investigate the associations between head and neck cancer (HNC) risk and occupations. - METHODS: We harmonized data on occupations in a pooled analysis of 8839 HNC cases and 13,730 controls in International Head and Neck Cancer Epidemiology (INHANCE) consortium. Logistic regression was used to estimate odds ratios (ORs) for associations of occupations and HNC risk. Population attributable fraction (PAF) for occupations was calculated using the formula PEC×(OR-1)/OR. - RESULTS: Trend of increasing HNC risk was found with increasing duration of employment for many occupations, including cooks (OR=1.36; 95% confidence interval [CI] 1.09 to 1.68), cleaners (OR=1.38; 95% CI 1.13 to 1.69), painters (OR=1.82; 95% CI 1.42 to 2.35). The PAF for a priori occupations was 14.5% (95% CI 7.1% to 21.9%) for HNC. - CONCLUSIONS: We found associations between certain occupations and HNC risks, including for subsites, with a duration-response relationship.
Item Description:Gesehen am 14.08.2019
Physical Description:Online Resource
ISSN:1536-5948
DOI:10.1097/JOM.0000000000001563

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