Cancer stem cells in head and neck squamous cell carcinoma: identification, characterization and clinical implications
Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of can...
Guardado en:
| Autor principal: | |
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| Formato: | Article (Journal) |
| Lenguaje: | inglés |
| Publicado: |
2 May 2019
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| In: |
Cancers
Year: 2019, Volumen: 11, Número: 5 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11050616 |
| Acceso en línea: | Verlag, Volltext: http://dx.doi.org/10.3390/cancers11050616
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| Notas de Autor: | Claudia Peitzsch, Jacqueline Nathansen, Sebastian I. Schniewind, Franziska Schwarz and Anna Dubrovska |
| Sumario: | Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells. |
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| Notas: | Gesehen am 20.08.2019 |
| Descripción Física: | Online Resource |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers11050616 |