Stem cell-derived hepatocyte-like cells as model for viral hepatitis research
Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translationa...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
12 June 2019
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| In: |
Stem cells international
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| ISSN: | 1687-9678 |
| DOI: | 10.1155/2019/9605252 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1155/2019/9605252
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| Author Notes: | Jingjing Wang, Bingqian Qu, Fang Zhang, Cindy Zhang, Wanyan Deng, Viet Loan Dao Thi, and Yuchen Xia |
| Summary: | Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. Here we summarize the use of human stem cell-derived hepatocyte-like cells for hepatotropic virus infection studies, including the dissection of virus-host interactions and virus-induced pathogenesis as well as the identification and validation of novel antiviral agents. |
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| Item Description: | Gesehen am 26.08.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1687-9678 |
| DOI: | 10.1155/2019/9605252 |