Molecular dissection of large cell carcinomas of the lung with null immunophenotype
Summary - The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-spec...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 June 2018
|
| In: |
Pathology
Year: 2018, Jahrgang: 50, Heft: 5, Pages: 530-535 |
| ISSN: | 1465-3931 |
| DOI: | 10.1016/j.pathol.2018.03.005 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.pathol.2018.03.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0031302517307183 
|
| Verfasserangaben: | Alexander Harms, Volker Endris, Hauke Winter, Mark Kriegsmann, Albrecht Stenzinger, Peter Schirmacher, Arne Warth, Daniel Kazdal |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1672114101 | ||
| 003 | DE-627 | ||
| 005 | 20220816214116.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190826s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.pathol.2018.03.005 |2 doi | |
| 035 | |a (DE-627)1672114101 | ||
| 035 | |a (DE-599)KXP1672114101 | ||
| 035 | |a (OCoLC)1341238567 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Harms, Alexander |d 1988- |e VerfasserIn |0 (DE-588)1065129408 |0 (DE-627)815640749 |0 (DE-576)424796996 |4 aut | |
| 245 | 1 | 0 | |a Molecular dissection of large cell carcinomas of the lung with null immunophenotype |c Alexander Harms, Volker Endris, Hauke Winter, Mark Kriegsmann, Albrecht Stenzinger, Peter Schirmacher, Arne Warth, Daniel Kazdal |
| 264 | 1 | |c 27 June 2018 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.08.2019 | ||
| 520 | |a Summary - The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of these tumours could depict additional therapeutic approaches. We analysed a cohort of 35 LCC diagnosed according to the 2004 WHO classification and reclassified them according to the criteria of the 2015 WHO classification. Subsequently, tumours with a null immunophenotype were analysed by targeted next generation sequencing (42 marker genes including TP53, EGFR, KRAS, STK11 and SMARC4A) and fluorescence in situ hybridisation (ROS1, ALK). By applying the criteria of the 2015 WHO classification and subsequent molecular subtyping we could show that out of 35 previously diagnosed LCC, 16 cases could be reclassified into specific NSCLC subtypes using immunohistochemistry. Additionally, based on their mutational pattern, eight of the remaining 19 cases with null immunophenotype could be assigned as ‘favour adenocarcinoma’. We demonstrate that molecular subtyping is helpful to further categorise LCC with null immunophenotype. Our findings argue for an algorithm including stratified molecular analysis of all respective cases. | ||
| 650 | 4 | |a Large cell carcinoma | |
| 650 | 4 | |a lung | |
| 650 | 4 | |a next generation sequencing | |
| 700 | 1 | |a Endris, Volker |e VerfasserIn |0 (DE-588)1063753686 |0 (DE-627)812590961 |0 (DE-576)422898198 |4 aut | |
| 700 | 1 | |a Winter, Hauke |e VerfasserIn |0 (DE-588)1162076038 |0 (DE-627)1025509773 |0 (DE-576)176791531 |4 aut | |
| 700 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 700 | 1 | |a Stenzinger, Albrecht |e VerfasserIn |0 (DE-588)139606106 |0 (DE-627)703395238 |0 (DE-576)312432755 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Warth, Arne |d 1979- |e VerfasserIn |0 (DE-588)132646145 |0 (DE-627)524716927 |0 (DE-576)260019755 |4 aut | |
| 700 | 1 | |a Kazdal, Daniel |d 1983- |e VerfasserIn |0 (DE-588)114929650X |0 (DE-627)1009614088 |0 (DE-576)496635867 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pathology |d Amsterdam : Elsevier, 1969 |g 50(2018), 5, Seite 530-535 |h Online-Ressource |w (DE-627)271178310 |w (DE-600)1479244-8 |w (DE-576)079234585 |x 1465-3931 |7 nnas |a Molecular dissection of large cell carcinomas of the lung with null immunophenotype |
| 773 | 1 | 8 | |g volume:50 |g year:2018 |g number:5 |g pages:530-535 |g extent:6 |a Molecular dissection of large cell carcinomas of the lung with null immunophenotype |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.pathol.2018.03.005 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0031302517307183 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190826 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 114929650X |a Kazdal, Daniel |m 114929650X:Kazdal, Daniel |d 910000 |d 912000 |e 910000PK114929650X |e 912000PK114929650X |k 0/910000/ |k 1/910000/912000/ |p 8 |y j | ||
| 998 | |g 132646145 |a Warth, Arne |m 132646145:Warth, Arne |d 910000 |d 912000 |e 910000PW132646145 |e 912000PW132646145 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 139606106 |a Stenzinger, Albrecht |m 139606106:Stenzinger, Albrecht |d 910000 |d 912000 |e 910000PS139606106 |e 912000PS139606106 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 912000 |e 910000PK103740324X |e 912000PK103740324X |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 1162076038 |a Winter, Hauke |m 1162076038:Winter, Hauke |d 910000 |e 910000PW1162076038 |k 0/910000/ |p 3 | ||
| 998 | |g 1063753686 |a Endris, Volker |m 1063753686:Endris, Volker |d 910000 |d 912000 |e 910000PE1063753686 |e 912000PE1063753686 |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 1065129408 |a Harms, Alexander |m 1065129408:Harms, Alexander |d 910000 |d 912000 |e 910000PH1065129408 |e 912000PH1065129408 |k 0/910000/ |k 1/910000/912000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1672114101 |e 3508888134 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"name":{"displayForm":["Alexander Harms, Volker Endris, Hauke Winter, Mark Kriegsmann, Albrecht Stenzinger, Peter Schirmacher, Arne Warth, Daniel Kazdal"]},"note":["Gesehen am 26.08.2019"],"person":[{"given":"Alexander","display":"Harms, Alexander","family":"Harms","role":"aut"},{"given":"Volker","display":"Endris, Volker","role":"aut","family":"Endris"},{"display":"Winter, Hauke","given":"Hauke","role":"aut","family":"Winter"},{"family":"Kriegsmann","role":"aut","display":"Kriegsmann, Mark","given":"Mark"},{"given":"Albrecht","display":"Stenzinger, Albrecht","family":"Stenzinger","role":"aut"},{"given":"Peter","display":"Schirmacher, Peter","role":"aut","family":"Schirmacher"},{"family":"Warth","role":"aut","display":"Warth, Arne","given":"Arne"},{"given":"Daniel","display":"Kazdal, Daniel","role":"aut","family":"Kazdal"}],"recId":"1672114101","physDesc":[{"extent":"6 S."}],"id":{"eki":["1672114101"],"doi":["10.1016/j.pathol.2018.03.005"]},"title":[{"title_sort":"Molecular dissection of large cell carcinomas of the lung with null immunophenotype","title":"Molecular dissection of large cell carcinomas of the lung with null immunophenotype"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"27 June 2018","dateIssuedKey":"2018"}],"relHost":[{"language":["eng"],"part":{"volume":"50","year":"2018","extent":"6","pages":"530-535","issue":"5","text":"50(2018), 5, Seite 530-535"},"note":["Gesehen am 09.11.2023"],"pubHistory":["1.1969 -"],"disp":"Molecular dissection of large cell carcinomas of the lung with null immunophenotypePathology","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"271178310","title":[{"subtitle":"the journal of the Royal College of Pathologists of Australasia","title":"Pathology","title_sort":"Pathology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1479244-8"],"issn":["1465-3931"],"eki":["271178310"]},"origin":[{"publisher":"Elsevier ; Taylor & Francis Group ; Informa Healthcare ; Wolters Kluwer Lippincott Williams & Wilkins","dateIssuedDisp":"1969-","dateIssuedKey":"1969","publisherPlace":"Amsterdam ; Abingdon ; London [u.a.] ; London [u.a.]"}]}]} | ||
| SRT | |a HARMSALEXAMOLECULARD2720 | ||