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Allostery in its many disguises: from theory to applications

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A coll...

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Main Authors: Wodak, Shoshana J. (Author) , Paci, Emanuele (Author) , Dokholyan, Nikolay V. (Author) , Berezovsky, Igor N. (Author) , Horovitz, Amnon (Author) , Li, Jing (Author) , Hilser, Vincent J. (Author) , Bahar, Ivet (Author) , Karanicolas, John (Author) , Stock, Gerhard (Author) , Hamm, Peter (Author) , Stote, Roland H. (Author) , Eberhardt, Jerome (Author) , Chebaro, Yassmine (Author) , Dejaegere, Annick (Author) , Cecchini, Marco (Author) , Changeux, Jean-Pierre (Author) , Bolhuis, Peter G. (Author) , Vreede, Jocelyne (Author) , Faccioli, Pietro (Author) , Orioli, Simone (Author) , Ravasio, Riccardo (Author) , Yan, Le (Author) , Brito, Carolina (Author) , Wyart, Matthieu (Author) , Gkeka, Paraskevi (Author) , Rivalta, Ivan (Author) , Palermo, Giulia (Author) , McCammon, J. Andrew (Author) , Panecka-Hofman, Joanna (Author) , Wade, Rebecca C. (Author) , Di Pizio, Antonella (Author) , Niv, Masha Y. (Author) , Nussinov, Ruth (Author) , Tsai, Chung-Jung (Author) , Jang, Hyunbum (Author) , Padhorny, Dzmitry (Author) , Kozakov, Dima (Author) , McLeish, Tom (Author)
Format: Article (Journal)
Language:English
Published: 7 February 2019
In: Structure
Year: 2019, Volume: 27, Issue: 4, Pages: 566-578
ISSN:1878-4186
DOI:10.1016/j.str.2019.01.003
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.str.2019.01.003
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0969212619300036
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Author Notes:Shoshana J. Wodak, Emanuele Paci, Nikolay V. Dokholyan, Igor N. Berezovsky, Amnon Horovitz, Jing Li, Vincent J. Hilser, Ivet Bahar, John Karanicolas, Gerhard Stock, Peter Hamm, Roland H. Stote, Jerome Eberhardt, Yassmine Chebaro, Annick Dejaegere, Marco Cecchini, Jean-Pierre Changeux, Peter G. Bolhuis, Jocelyne Vreede, Pietro Faccioli, Simone Orioli, Riccardo Ravasio, Le Yan, Carolina Brito, Matthieu Wyart, Paraskevi Gkeka, Ivan Rivalta, Giulia Palermo, J. Andrew McCammon, Joanna Panecka-Hofman, Rebecca C. Wade, Antonella Di Pizio, Masha Y. Niv, Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang, Dzmitry Padhorny, Dima Kozakov, and Tom McLeish
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Summary:Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM (Center Européen de Calcul Atomique et Moléculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.
Item Description:Gesehen am 27.08.2019
Physical Description:Online Resource
ISSN:1878-4186
DOI:10.1016/j.str.2019.01.003

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