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microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary str...

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Bibliographic Details
Main Authors: Schult, Philipp (Author) , Roth, Hanna (Author) , Adams, Rebecca L. (Author) , Mas, Caroline (Author) , Imbert, Lionel (Author) , Orlik, Christian (Author) , Ruggieri, Alessia (Author) , Pyle, Anna M. (Author) , Lohmann, Volker (Author)
Format: Article (Journal)
Language:English
Published: 04 July 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-05053-3
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-018-05053-3
Verlag, Volltext: https://www.nature.com/articles/s41467-018-05053-3
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Author Notes:Philipp Schult, Hanna Roth, Rebecca L. Adams, Caroline Mas, Lionel Imbert, Christian Orlik, Alessia Ruggieri, Anna M. Pyle & Volker Lohmann
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Summary:The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by preventing energetically more favorable secondary structures within the HCV RNA genome.
Item Description:Gesehen am 27.08.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-05053-3

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