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Beta-blockers and ACE inhibitors are associated with improved survival secondary to ventricular tachyarrhythmia

Objective: The study sought to assess the impact of treatment with beta-blocker (BB) or ACE inhibitor/angiotensin receptor blocker (ACEi/ARB) on secondary survival in patients presenting with ventricular tachyarrhythmia. Background: Data regarding outcome of patients presenting with ventricular tach...

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Main Authors: Schupp, Tobias (Author) , Behnes, Michael (Author) , Weiß, Christel (Author) , Lang, Siegfried (Author) , Reiser, Linda (Author) , Kern-Bollow, Armin (Author) , Taton, Gabriel (Author) , Reichelt, Thomas (Author) , Ellguth, Dominik (Author) , Engelke, Niko (Author) , Ansari, Uzair (Author) , El-Battrawy, Ibrahim (Author) , Borggrefe, Martin (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 3 August 2018
In: Cardiovascular drugs and therapy
Year: 2018, Volume: 32, Issue: 4, Pages: 353-363
ISSN:1573-7241
DOI:10.1007/s10557-018-6812-z
Online Access:Verlag, Volltext: https://doi.org/10.1007/s10557-018-6812-z
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Author Notes:Tobias Schupp, Michael Behnes, Christel Weiß, Christoph Nienaber, Siegfried Lang, Linda Reiser, Armin Bollow, Gabriel Taton, Thomas Reichelt, Dominik Ellguth, Niko Engelke, Uzair Ansari, Ibrahim El-Battrawy, Thomas Bertsch, Muharrem Akin, Kambis Mashayekhi, Martin Borggrefe, Ibrahim Akin
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Summary:Objective: The study sought to assess the impact of treatment with beta-blocker (BB) or ACE inhibitor/angiotensin receptor blocker (ACEi/ARB) on secondary survival in patients presenting with ventricular tachyarrhythmia. Background: Data regarding outcome of patients presenting with ventricular tachyarrhythmia treated with BB and ACEi/ARB is limited. Methods: A large retrospective registry was used including consecutive patients presenting with ventricular tachycardia and fibrillation from 2002 to 2016 on admission. Applying propensity-score matching for harmonization, the impact of “BB” and “ACEi/ARB” was comparatively evaluated. The primary prognostic outcome was long-term all-cause death at 3 years. Results: A total of 972 matched patients were included. Both patients with BB (long-term mortality rate 18 versus 27%; log rank p = 0.041; HR = 0.661; 95% CI = 0.443-0.986; p = 0.043) and with ACEi/ARB (long-term mortality rate 13 versus 23%; log rank p = 0.004; HR = 0.544; 95% CI = 0.359-0.824; p = 0.004) revealed better secondary survival compared to patients without after presenting with ventricular tachyarrhythmia on admission. The prognostic benefit of BB was comparable to ACEi/ARB (long-term mortality rate 21 versus 26%; log rank p = 0.539). Conclusion: BB and ACEi/ARB were associated with improved secondary survival in patients surviving ventricular tachyarrhythmia on admission.
Item Description:Gesehen am 28.08.2019
Physical Description:Online Resource
ISSN:1573-7241
DOI:10.1007/s10557-018-6812-z

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