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Necroptosis microenvironment directs lineage commitment in liver cancer

The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

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Bibliographic Details
Main Authors: Seehawer, Marco (Author) , Heinzmann, Florian (Author) , D’Artista, Luana (Author) , Harbig, Jule (Author) , Roux, Pierre-François (Author) , Hoenicke, Lisa (Author) , Dang, Hien (Author) , Klotz, Sabrina (Author) , Robinson, Lucas (Author) , Doré, Grégory (Author) , Rozenblum, Nir (Author) , Kang, Tae-Won (Author) , Chawla, Rishabh (Author) , Buch, Thorsten (Author) , Vucur, Mihael (Author) , Roth, Mareike (Author) , Zuber, Johannes (Author) , Luedde, Tom (Author) , Sipos, Bence (Author) , Longerich, Thomas (Author) , Heikenwälder, Mathias (Author) , Wang, Xin Wei (Author) , Bischof, Oliver (Author) , Zender, Lars (Author)
Format: Article (Journal)
Language:English
Published: 12 September 2018
In: Nature
Year: 2018, Volume: 562, Issue: 7725, Pages: 69-75
ISSN:1476-4687
DOI:10.1038/s41586-018-0519-y
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41586-018-0519-y
Verlag, Volltext: https://www.nature.com/articles/s41586-018-0519-y
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Author Notes:Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof & Lars Zender
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Summary:The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.
Item Description:Gesehen am 04.09.2019
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/s41586-018-0519-y

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