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Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma

PurposeIn patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study wa...

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Main Authors: Heinzelmann, Frank (Author) , Bethge, Wolfgang Andreas (Author) , Beelen, Dietrich W. (Author) , Stelljes, Matthias (Author) , Dreger, Peter (Author) , Engelhard, Marianne (Author) , Finke, Jürgen (Author) , Kröger, Nicolaus (Author) , Holler, Ernst (Author) , Bornhäuser, Martin (Author) , Müller, Annerose (Author) , Haubitz, Imme (Author) , Ottinger, Hellmut (Author)
Format: Article (Journal)
Language:English
Published: June 2018
In: Journal of cancer research and clinical oncology
Year: 2018, Volume: 144, Issue: 6, Pages: 1173-1183
ISSN:1432-1335
DOI:10.1007/s00432-018-2633-5
Online Access:Verlag, Volltext: https://doi.org/10.1007/s00432-018-2633-5
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Author Notes:Frank Heinzelmann, Wolfgang Bethge, Dietrich Wilhelm Beelen, Matthias Stelljes, Peter Dreger, Marianne Engelhard, Jürgen Finke, Nikolaus Kröger, Ernst Holler, Martin Bornhäuser, Annerose Müller, Imme Haubitz, Hellmut Ottinger
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Summary:PurposeIn patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study was to define the actual significance of allo-HCT in treatment of tFL.MethodsThe database of the German Registry for Stem Cell Transplantation (DRST) was screened for patients who underwent allo-HCT for tFL 1998-2008. Confirmation of tFL-diagnosis by local and/or pathologists of the National NHL Board was mandatory for enrolment. Gaps in reported EBMT Minimum Essential Data datasets (MED-A) were filled by local DRST data managers. Relevant HCT outcome variables were evaluated by uni- and multivariate statistical analysis.ResultsMedian age of enrolled 33 patients was 51 years with a post allo-HCT median follow-up of 7.1 years of surviving patients. At time of HCT 24/33 patients had chemosensitive disease. In 24/33 patients reduced intensity conditioning (RIC) was used. Estimated 1, 2, 5-year overall survival (OS) and event-free survival rates were 49/39/33, and 33/30/24%. Cumulative 100 days non-relapse mortality was 25%. Chemosensitive disease, RIC, and limited chronic GvHD were identified as independent prognostic factors for OS.ConclusionsAllo-HCT offers the chance of cure for tFL.
Item Description:Gesehen am 24.09.2019
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-018-2633-5

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