AAV vector-mediated in vivo reprogramming into pluripotency
In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 July 2018
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| In: |
Nature Communications
Year: 2018, Jahrgang: 9 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05059-x |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41467-018-05059-x Verlag, Volltext: https://www.nature.com/articles/s41467-018-05059-x |
| Verfasserangaben: | Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano & Dirk Grimm |
| Zusammenfassung: | In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses. |
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| Beschreibung: | Gesehen am 25.09.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-018-05059-x |