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AAV vector-mediated in vivo reprogramming into pluripotency

In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

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Bibliographic Details
Main Authors: Senís Herrero, Elena (Author) , Mosteiro, Lluc (Author) , Wilkening, Stefan (Author) , Wiedtke, Ellen (Author) , Nowrouzi, Ali (Author) , Afzal, Saira (Author) , Fronza, Raffaele (Author) , Landerer, Henrik (Author) , Abad, Maria (Author) , Niopek, Dominik (Author) , Schmidt, Manfred (Author) , Serrano, Manuel (Author) , Grimm, Dirk (Author)
Format: Article (Journal)
Language:English
Published: 09 July 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-018-05059-x
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-018-05059-x
Verlag, Volltext: https://www.nature.com/articles/s41467-018-05059-x
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Author Notes:Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano & Dirk Grimm
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Summary:In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.
Item Description:Gesehen am 25.09.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-018-05059-x

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