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Glutamatergic synaptic input to glioma cells drives brain tumour progression

Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.

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Main Authors: Venkataramani, Varun (Author) , Tanev, Dimitar Ivanov (Author) , Strahle, Christopher (Author) , Studier-Fischer, Alexander (Author) , Fankhauser, Laura (Author) , Keßler, Tobias (Author) , Körber, Christoph (Author) , Kardorff, Markus (Author) , Ratliff, Miriam (Author) , Xie, Ruifan (Author) , Horstmann, Heinz (Author) , Messer, Mirko (Author) , Paik, Sang (Author) , Knabbe, Johannes (Author) , Sahm, Felix (Author) , Kurz, Felix T. (Author) , Açıkgöz, Azer Aylin (Author) , Herrmannsdörfer, Frank (Author) , Agarwal, Amit (Author) , Bergles, Dwight E. (Author) , Chalmers, Anthony (Author) , Miletic, Hrvoje (Author) , Turcan, S̨evin (Author) , Mawrin, Christian (Author) , Hänggi, Daniel (Author) , Liu, Hai-Kun (Author) , Wick, Wolfgang (Author) , Winkler, Frank (Author) , Kuner, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 18 September 2019
In: Nature
Year: 2019, Volume: 573, Issue: 7775, Pages: 532-538
ISSN:1476-4687
DOI:10.1038/s41586-019-1564-x
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41586-019-1564-x
Verlag: https://www.nature.com/articles/s41586-019-1564-x
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Author Notes:Varun Venkataramani, Dimitar Ivanov Tanev, Christopher Strahle, Alexander Studier-Fischer, Laura Fankhauser, Tobias Kessler, Christoph Körber, Markus Kardorff, Miriam Ratliff, Ruifan Xie, Heinz Horstmann, Mirko Messer, Sang Peter Paik, Johannes Knabbe, Felix Sahm, Felix T. Kurz, Azer Aylin Acikgöz, Frank Herrmannsdörfer, Amit Agarwal, Dwight E. Bergles, Anthony Chalmers, Hrvoje Miletic, Sevin Turcan, Christian Mawrin, Daniel Hänggi, Hai-Kun Liu, Wolfgang Wick, Frank Winkler, & Thomas Kuner
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Summary:Neurons form glutamatergic synapses with glioma cells in mice and humans, and inhibition of AMPA receptors reduces glioma cell invasion and growth.
Item Description:Gesehen am 30.09.2019
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/s41586-019-1564-x

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