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Reduction of transplant vasculopathy by intraoperative nucleic acid-based therapy in a mouse aortic allograft model

Transplant vasculopathy (TV) is the main limiting factor for long-term graft survival characterized by fibrosis, myofibroblast, and smooth muscle cell (SMC) proliferation. Decoy oligodeoxynucleotide (dODN) against the transcription factor activator protein-1 (AP-1) might interfere with the expressio...

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Bibliographic Details
Main Authors: Arif, Rawa (Author) , Remes, Anca (Author) , Zaradzki, Marcin (Author) , Hecker, Markus (Author) , Karck, Matthias (Author) , Wagner, Andreas H. (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: The thoracic and cardiovascular surgeon
Year: 2018, Volume: 67, Issue: 6, Pages: 503-512
ISSN:1439-1902
DOI:10.1055/s-0038-1673633
Online Access:Verlag, Volltext: https://doi.org/10.1055/s-0038-1673633
Verlag: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673633
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Author Notes:Rawa Arif, Maximilian Franz, Anca Remes, Marcin Zaradzki, Markus Hecker, Matthias Karck, Oliver J. Müller, Klaus Kallenbach, Andreas H. Wagner
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Summary:Transplant vasculopathy (TV) is the main limiting factor for long-term graft survival characterized by fibrosis, myofibroblast, and smooth muscle cell (SMC) proliferation. Decoy oligodeoxynucleotide (dODN) against the transcription factor activator protein-1 (AP-1) might interfere with the expression of AV-related genes that govern neointima formation.
Item Description:23. Oktober 2018 (eFirst)
Gesehen am 09.10.2019
Physical Description:Online Resource
ISSN:1439-1902
DOI:10.1055/s-0038-1673633

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