Reduction of transplant vasculopathy by intraoperative nucleic acid-based therapy in a mouse aortic allograft model
Transplant vasculopathy (TV) is the main limiting factor for long-term graft survival characterized by fibrosis, myofibroblast, and smooth muscle cell (SMC) proliferation. Decoy oligodeoxynucleotide (dODN) against the transcription factor activator protein-1 (AP-1) might interfere with the expressio...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
The thoracic and cardiovascular surgeon
Year: 2018, Jahrgang: 67, Heft: 6, Pages: 503-512 |
| ISSN: | 1439-1902 |
| DOI: | 10.1055/s-0038-1673633 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1055/s-0038-1673633 Verlag: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673633 
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| Verfasserangaben: | Rawa Arif, Maximilian Franz, Anca Remes, Marcin Zaradzki, Markus Hecker, Matthias Karck, Oliver J. Müller, Klaus Kallenbach, Andreas H. Wagner |
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| 520 | |a Transplant vasculopathy (TV) is the main limiting factor for long-term graft survival characterized by fibrosis, myofibroblast, and smooth muscle cell (SMC) proliferation. Decoy oligodeoxynucleotide (dODN) against the transcription factor activator protein-1 (AP-1) might interfere with the expression of AV-related genes that govern neointima formation. | ||
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