Virtues of volatility: a facile transesterification approach to boronic acids
Boronic acids are an increasingly important compound class for many applications, including C-C bond formation reactions, medicinal chemistry, and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. We describe an a...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 23, 2019
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| In: |
Organic letters
Year: 2019, Volume: 21, Issue: 9, Pages: 3048-3052 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b00584 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1021/acs.orglett.9b00584
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| Author Notes: | Stefan P.A. Hinkes, Christian D.P. Klein |
| Summary: | Boronic acids are an increasingly important compound class for many applications, including C-C bond formation reactions, medicinal chemistry, and diagnostics. The deprotection of boronic ester intermediates is frequently a problematic and inefficient step in boronic acid syntheses. We describe an approach that highly facilitates this transformation by leveraging the volatility of methylboronic acid and its diol esters. The method is performed under mild conditions, provides high yields, and eliminates cumbersome and problematic purification steps. |
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| Item Description: | Gesehen am 10.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b00584 |