Reference ranges and determinants of tricuspid regurgitation velocity in healthy adults assessed by two-dimensional Doppler-echocardiography
Background: Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). Objectives: To explore the physiologic range of TRV in healthy adults and to investigate its clinical...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2018
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| In: |
Respiration
Year: 2018, Volume: 96, Issue: 5, Pages: 425-433 |
| ISSN: | 1423-0356 |
| DOI: | 10.1159/000490191 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1159/000490191 Verlag, Volltext: https://www.karger.com/Article/FullText/490191 
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| Author Notes: | Alberto M. Marra, Robert Naeije, Francesco Ferrara, Olga Vriz, Anna Agnese Stanziola, Michele D’Alto, Antonello D’Andrea, Luca Carannante, Christina Alessandra Eichstaedt, Antonio Cittadini, Nicola Benjamin, Ekkehard Grünig, Eduardo Bossone |
| Summary: | Background: Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). Objectives: To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. Methods: In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE. In the second part, a pooled meta-analysis of 16 already published studies with TRV values in healthy subjects (<i>n</i> = 981) was performed. Statistical analysis included the calculation of 95% quantiles for defining reference ranges. Results: In the prospectively enrolled cohort, mean TRV was 2.01 ± 0.29 m/s (5-95% CI 1.987-2.033 m/s). It was significantly but weakly positively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, left atrial volume and negative with mitral inflow E/A ratio. No significant differences were found between males and females. The prospectively enrolled data revealed similar values to the literature-based datasets resulting in a mean TRV of 1.96 m/s (95% CI 1.91-2.02 m/s) and a 95% quantile of 2.55 m/s.Conclusions: To the best of our knowledge, this is the largest dataset to describe reference ranges of TRV and their clinical determinants in healthy adults years. The determined cut-off value of 2.55 m/s of this study has to be confirmed in specific pathologies such as patients at risk of PH. |
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| Item Description: | Gesehen am 14.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1423-0356 |
| DOI: | 10.1159/000490191 |