Iron(III) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity
Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (e.g., hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(III) coordination and pH were suggested to be critical for bioactivation steps...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[2018]
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| In: |
New journal of chemistry
Year: 2018, Volume: 42, Issue: 10, Pages: 8074-8087 |
| ISSN: | 1369-9261 |
| DOI: | 10.1039/C7NJ04867J |
| Online Access: | Verlag, Volltext: https://doi.org/10.1039/C7NJ04867J Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2018/nj/c7nj04867j 
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| Author Notes: | X. Martin-Benlloch, A. Novodomska, D. Jacquemin, E. Davioud-Charvet and M. Elhabiri |
| Summary: | Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (e.g., hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(III) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(III) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution. |
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| Item Description: | Gesehen am 14.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1369-9261 |
| DOI: | 10.1039/C7NJ04867J |