The role of organ- and function-preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx
BACKGROUND: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx. - METHODS: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regardin...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2019
|
| In: |
Head & neck
Year: 2019, Volume: 41, Issue: 7, Pages: 2208-2214 |
| ISSN: | 1097-0347 |
| Online Access: |
|
| Author Notes: | Sati Akbaba, Kristin Lang, Olcay Cem Bulut, Thomas Held, Stefan Rieken, Peter Plinkert, Alexandra Jensen, Klaus Herfarth, Juergen Debus, Sebastian Adeberg |
| Summary: | BACKGROUND: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx. - METHODS: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regarding survival and treatment-related toxicity with the focus on functional larynx preservation. - RESULTS: Median follow-up was 45 months. RT offered an excellent 5-year local control (LC) rate of 100%. Eight of 11 patients were treated with a laryngeal preservation approach (LPA). At last follow-up, only one of these eight patients developed a local recurrence requiring a total laryngectomy 11 years after treatment. Severe toxicity was uncommon, with only one patient with LPA, requiring a temporary tracheostomy during therapy. - CONCLUSIONS: RT is an effective treatment method for laryngeal ACC with excellent LC rates, preservation of the laryngeal function and voice formation, representing a valuable therapy alternative to total laryngectomy. |
|---|---|
| Item Description: | Gesehen am 15.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1097-0347 |