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Endothelial cell fitness dictates the source of regenerating liver vasculature

Graphical Abstract - <img class="fragment-image" alt="Figure1" src="http://jem.rupress.org/content/jem/215/10/2497/F1.medium.jpg" width="440" height="379"/>Download figureOpen in new tabDownload powerpoint - - Neoangiogenesis plays a key role...

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Main Authors: Singhal, Mahak (Author) , Liu, Xiaoting (Author) , Inverso, Donato (Author) , Jiang, Kai (Author) , Dai, Jianing (Author) , He, Hao (Author) , Bartels, Susanne (Author) , Li, Weiping (Author) , Abdul Pari, Ashik Ahmed (Author) , Gengenbacher, Nicolas (Author) , Besemfelder, Eva (Author) , Hui, Lijian (Author) , Augustin, Hellmut (Author) , Hu, Junhao (Author)
Format: Article (Journal)
Language:English
Published: 7 September, 2018
In: Journal of experimental medicine
Year: 2018, Volume: 215, Issue: 10, Pages: 2497-2508
ISSN:1540-9538
DOI:10.1084/jem.20180008
Online Access:Verlag, Volltext: https://doi.org/10.1084/jem.20180008
Verlag, Volltext: http://jem.rupress.org/content/215/10/2497
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Author Notes:Mahak Singhal, Xiaoting Liu, Donato Inverso, Kai Jiang, Jianing Dai, Hao He, Susanne Bartels, Weiping Li, Ashik Ahmed Abdul Pari, Nicolas Gengenbacher, Eva Besemfelder, Lijian Hui, Hellmut G. Augustin, and Junhao Hu
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Summary:Graphical Abstract - <img class="fragment-image" alt="Figure1" src="http://jem.rupress.org/content/jem/215/10/2497/F1.medium.jpg" width="440" height="379"/>Download figureOpen in new tabDownload powerpoint - - Neoangiogenesis plays a key role in diverse pathophysiological conditions, including liver regeneration. Yet, the source of new endothelial cells (ECs) remains elusive. By analyzing the regeneration of the liver vasculature in irradiation-based myeloablative and nonmyeloablative bone marrow transplantation mouse models, we discovered that neoangiogenesis in livers with intact endothelium was solely mediated by proliferation of resident ECs. However, following irradiation-induced EC damage, bone marrow-derived mononuclear cells were recruited and incorporated into the vasculature. Further experiments with direct bone marrow infusion or granulocyte colony-stimulating factor (G-CSF)-mediated progenitor cell mobilization, which resembles clinically relevant stem cell therapy, demonstrated that bone marrow-derived cells did not contribute to the regeneration of liver vasculature after two-thirds partial hepatectomy (PHx). Taken together, the data reconcile many of the discrepancies in the literature and highlight that the cellular source of regenerating endothelium depends on the fitness of the residual vasculature.
Item Description:Gesehen am 16.10.2019
Physical Description:Online Resource
ISSN:1540-9538
DOI:10.1084/jem.20180008

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