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NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol...

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Bibliographic Details
Main Authors: Höglinger, Doris (Author) , Burgoyne, T. (Author) , Sanchez-Heras, E. (Author) , Colaco, A. (Author) , Newton, J. (Author) , Hempelmann, Pia (Author) , Platt, Farina Marie (Author) , Eden, Emily R. (Author)
Format: Article (Journal)
Language:English
Published: 19 September 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-12152-2
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41467-019-12152-2
Verlag: https://www.nature.com/articles/s41467-019-12152-2
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Author Notes:D. Höglinger, T. Burgoyne, E. Sanchez-Heras, P. Hartwig, A. Colaco, J. Newton, C.E. Futter, S. Spiegel, F.M. Platt and E.R. Eden
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Summary:Though endocytosed dietary cholesterol is transferred to the endoplasmic reticulum (ER), how this is regulated is unclear. Here, the authors report a role for Niemann-Pick Type C Protein 1 (NPC1) in tethering endocytic organelles to the ER, which may contribute to interorganelle cholesterol transport.
Item Description:Gesehen am 21.10.2019
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-12152-2

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