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Extending the time window for intravenous thrombolysis in acute ischemic stroke using magnetic resonance imaging-based patient selection

Background: Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke. We studied whether acute ischemic stroke patients with penumbral tissue identified on magnetic resonance imaging 4.5-9 h after symptom onset...

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Bibliographic Details
Main Authors: Ringleb, Peter A. (Author) , Bendszus, Martin (Author) , Fatar, Marc (Author) , Hacke, Werner (Author)
Format: Article (Journal)
Language:English
Published: April 4, 2019
In: International journal of stroke
Year: 2019, Volume: 14, Issue: 5, Pages: 483-490
ISSN:1747-4949
DOI:10.1177/1747493019840938
Online Access:Verlag, Volltext: https://doi.org/10.1177/1747493019840938
Verlag: http://journals.sagepub.com/doi/10.1177/1747493019840938
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Author Notes:Peter Ringleb, Martin Bendszus, Erich Bluhmki, Geoffrey Donnan, Christoph Eschenfelder, Marc Fatar, Christof Kessler, Carlos Molina, Didier Leys, Girish Muddegowda, Sven Poli, Peter Schellinger, Stefan Schwab, Joaquin Serena, Danilo Toni, Nils Wahlgren and Werner Hacke, for the ECASS-4 study group
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Summary:Background: Intravenous thrombolysis with alteplase within a time window up to 4.5 h is the only approved pharmacological treatment for acute ischemic stroke. We studied whether acute ischemic stroke patients with penumbral tissue identified on magnetic resonance imaging 4.5-9 h after symptom onset benefit from intravenous thrombolysis compared to placebo.
Item Description:Gesehen am 21.10.2019
Physical Description:Online Resource
ISSN:1747-4949
DOI:10.1177/1747493019840938

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