Context encoding enables machine learning-based quantitative photoacoustics
Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. Although photoacoustic (PA) imaging is a modality with great potential to measure opt...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 18, 2018
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| In: |
Journal of biomedical optics
Year: 2018, Volume: 23, Issue: 5 |
| ISSN: | 1560-2281 |
| DOI: | 10.1117/1.JBO.23.5.056008 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1117/1.JBO.23.5.056008 Verlag: https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-23/issue-5/056008/Context-encoding-enables-machine-learning-based-quantitative-photoacoustics/10.1117/1.JBO.23.5.056008.short 
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| Author Notes: | Thomas Kirchner, Janek Gröhl, and Lena Maier-Hein |
| Summary: | Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. Although photoacoustic (PA) imaging is a modality with great potential to measure optical absorption deep inside tissue, quantification of the measurements remains a major challenge. We introduce the first machine learning-based approach to quantitative PA imaging (qPAI), which relies on learning the fluence in a voxel to deduce the corresponding optical absorption. The method encodes relevant information of the measured signal and the characteristics of the imaging system in voxel-based feature vectors, which allow the generation of thousands of training samples from a single simulated PA image. Comprehensive in silico experiments suggest that context encoding-qPAI enables highly accurate and robust quantification of the local fluence and thereby the optical absorption from PA images. |
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| Item Description: | Gesehen am 22.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1560-2281 |
| DOI: | 10.1117/1.JBO.23.5.056008 |