Human endogenous retroviruses: residues of ancient times are differentially expressed in Crohn’s disease
Eight percent of the human genome consists of human endogenous retroviruses (HERV). These genetic elements are remnants of ancient retroviral germ-line infections. Altered HERV expression is associated with several chronic inflammatory diseases. A physiological role of the HERV-derived proteins sync...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 21, 2018
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| In: |
Inflammatory intestinal diseases
Year: 2018, Volume: 3, Issue: 3, Pages: 125-137 |
| ISSN: | 2296-9365 |
| DOI: | 10.1159/000494026 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1159/000494026 Verlag: https://www.karger.com/Article/FullText/494026 
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| Author Notes: | Thomas Klag, Lioba Courth, Maureen J. Ostaff, German Ott, Eduard F. Stange, Nisar P. Malek, Wolfgang Seifarth, Jan Wehkamp |
| Summary: | Eight percent of the human genome consists of human endogenous retroviruses (HERV). These genetic elements are remnants of ancient retroviral germ-line infections. Altered HERV expression is associated with several chronic inflammatory diseases. A physiological role of the HERV-derived proteins syncytin-1 and -2 has been described for the integrity of the human placental cell layer in terms of maintaining feto-maternal tolerance. The aim of this project was to investigate HERV expression in Crohn’s disease (CD) with a further focus on syncytins in the gut. |
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| Item Description: | Gesehen am 24.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2296-9365 |
| DOI: | 10.1159/000494026 |