Treatment of adrenal metastases with conventional or hypofractionated image-guided radiation therapy: patterns and outcomes
Background/Aim: Metastases involving the adrenal glands can be treated surgically or with radiation therapy. Retrospective studies indicate that radiotherapy for this indication is safe, well-tolerated and associated with symptom palliation and good local control. We conducted this analysis to repor...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Anticancer research
Year: 2018, Volume: 38, Issue: 8, Pages: 4789-4796 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.12788 |
| Online Access: | Verlag, Volltext: https://doi.org/10.21873/anticanres.12788 Verlag: http://ar.iiarjournals.org/content/38/8/4789 
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| Author Notes: | Daniel Buergy, Leonie Rabe, Kerstin Siebenlist, Florian Stieler, Jens Fleckenstein, Frank A. Giordano, Frederik Wenz and Judit Boda-Heggemann |
| Summary: | Background/Aim: Metastases involving the adrenal glands can be treated surgically or with radiation therapy. Retrospective studies indicate that radiotherapy for this indication is safe, well-tolerated and associated with symptom palliation and good local control. We conducted this analysis to report on patterns and outcomes of patients with adrenal metastases treated with hypo- or conventionally fractionated image-guided radiotherapy. Patients and Methods: Patients with adrenal metastases from solid tumors treated at our department between 01/2010-12/2017 were reviewed. A total of 22 lesions were treated in 18 patients with a median dose of 35 Gy (20-60 Gy) in a median number of 7 (4-25) fractions. Results: No grade ≥3 toxicity occurred. Median overall survival was 11.9 months. Five local failures occurred (22.7%). Lesion sizes or radiation dose were not correlated with local control. Patients treated for oligometastatic and oligoprogressive disease had a median overall survival of 33 and 6.5 months, respectively (palliative/polymetastatic: 1.6 months). Symptoms improved in all patients treated for clinically apparent lesions. Conclusion: Stereotactic radiotherapy of adrenal metastases was safe and effective in patients with oligometastases or oligoprogression. In palliative patients, short-course radiotherapy complemented with supportive care should be preferred. |
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| Item Description: | Gesehen am 24.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.12788 |