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Systematic review of the pharmacological agents that have been tested against spreading depolarizations

Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article w...

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Bibliographic Details
Main Authors: Klass, Anna (Author) , Sánchez-Porras, Renán (Author) , Santos, Edgar (Author)
Format: Article (Journal)
Language:English
Published: April 20, 2018
In: Journal of cerebral blood flow & metabolism
Year: 2018, Volume: 38, Issue: 7, Pages: 1149-1179
ISSN:1559-7016
DOI:10.1177/0271678X18771440
Online Access:Resolving-System, Volltext: https://doi.org/10.1177/0271678X18771440
Verlag: https://journals.sagepub.com/doi/10.1177/0271678X18771440
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Author Notes:Anna Klass, Renan Sánchez-Porras and Edgar Santos
Description
Summary:Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD. We present a variety of strategies that have been proposed to overcome the notorious harmfulness and pharmacoresistance of SD. Information on clinically used anesthetic, sedative, hypnotic agents, anti-migraine drugs, anticonvulsants and various other substances have been compiled and reviewed with respect to the efficacy against SD, in order to answer the question of whether a drug at safe doses could be of therapeutic use against SD in humans.
Item Description:Gesehen am 28.10.2019
Physical Description:Online Resource
ISSN:1559-7016
DOI:10.1177/0271678X18771440

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