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A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice

NY-BR-1 has been described as a breast cancer associated differentiation antigen with intrinsic immunogenicity giving rise to endogenous T and B cell responses. The current study presents the first murine tumor model allowing functional investigation of NY-BR-1-specific immune responses in vivo.

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Bibliographic Details
Main Authors: Das, Krishna (Author) , Eisel, David (Author) , Vormehr, Mathias (Author) , Müller-Decker, Karin (Author) , Hommertgen, Adriane (Author) , Jäger, Dirk (Author) , Zörnig, Inka (Author) , Feuerer, Markus (Author) , Kopp-Schneider, Annette (Author) , Osen, Wolfram (Author) , Eichmüller, Stefan B. (Author)
Format: Article (Journal)
Language:English
Published: 13 September 2019
In: BMC cancer
Year: 2019, Volume: 19, Pages: 914
ISSN:1471-2407
DOI:10.1186/s12885-019-6102-6
Online Access:Verlag, Volltext: https://doi.org/10.1186/s12885-019-6102-6
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Author Notes:Krishna Das, David Eisel, Mathias Vormehr, Karin Müller-Decker, Adriane Hommertgen, Dirk Jäger, Inka Zörnig, Markus Feuerer, Annette Kopp-Schneider, Wolfram Osen and Stefan B. Eichmüller
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Summary:NY-BR-1 has been described as a breast cancer associated differentiation antigen with intrinsic immunogenicity giving rise to endogenous T and B cell responses. The current study presents the first murine tumor model allowing functional investigation of NY-BR-1-specific immune responses in vivo.
Item Description:Gesehen am 30.10.2019
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-019-6102-6

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