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Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer

The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang...

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Main Authors: Schölch, Sebastian (Author) , Rahbari, Mohammad (Author) , Schneider, Martin (Author) , Reißfelder, Christoph (Author) , Rahbari, Nuh Nabi (Author)
Format: Article (Journal)
Language:English
Published: 29 July 2019
In: Scientific reports
Year: 2019, Volume: 9
ISSN:2045-2322
DOI:10.1038/s41598-019-47429-5
Online Access:Verlag, Volltext: https://doi.org/10.1038/s41598-019-47429-5
Verlag: https://www.nature.com/articles/s41598-019-47429-5
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Author Notes:Sebastian Schölch, Andreas Bogner, Ulrich Bork, Mohammad Rahbari, Balázs Győrffy, Martin Schneider, Christoph Reissfelder, Jürgen Weitz & Nuh N. Rahbari
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Summary:The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p = 0.029; VC: HR 1.091; p = 0.009). Conversely, elevated EGF is associated with favorable DFS (TC: HR 0.998; p = 0.045; VC: HR 0.998; p = 0.018) but not OS (TC: p = 0.201; VC: p = 0.453). None of the other angiogenic cytokines correlated with prognosis. The prognostic value of PlGF (OS + DFS) and EGF (DFS) was confirmed in both independent retrospective cohorts. Serum PlGF and EGF may serve as prognostic markers in non-metastatic CRC.
Item Description:Gesehen am 29.10.2019
Physical Description:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-019-47429-5

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