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Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer

PurposeTo review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response.MethodsA systematic literature sear...

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Bibliographic Details
Main Authors: Krug, David (Author) , Wenz, Frederik (Author)
Format: Article (Journal)
Language:English
Published: 30 January 2018
In: Strahlentherapie und Onkologie
Year: 2018, Volume: 194, Issue: 7, Pages: 607-618
ISSN:1439-099X
DOI:10.1007/s00066-018-1270-x
Online Access:Verlag, Volltext: https://doi.org/10.1007/s00066-018-1270-x
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Author Notes:David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Thomas Hehr, Marc D. Piroth, Felix Sedlmayer, Rainer Souchon, Frederik Wenz, Rolf Sauer
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Summary:PurposeTo review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response.MethodsA systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1st January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy.ResultsOut of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.ConclusionsThere is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.
Item Description:Gesehen am 30.10.2019
Physical Description:Online Resource
ISSN:1439-099X
DOI:10.1007/s00066-018-1270-x

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