Highly substituted medium-sized ring-fused azocinoquinoline scaffolds by post-Ugi-4CR reductive carbopalladation cyclization
A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2-dihydroazocino[4,3-b]quinolin-3-ones under mild reaction...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 30, 2019
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| In: |
The journal of organic chemistry
Year: 2019, Volume: 84, Issue: 17, Pages: 10740-10748 |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/acs.joc.9b01269 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1021/acs.joc.9b01269
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| Author Notes: | Helya Janatian Ghazvini, Thomas J. J. Müller, Frank Rominger, and Saeed Balalaie |
| Summary: | A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2-dihydroazocino[4,3-b]quinolin-3-ones under mild reaction conditions with good yields in short reaction time. |
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| Item Description: | Gesehen am 31.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/acs.joc.9b01269 |