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Routine liver elastography could predict actuarial survival after liver transplantation

Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. - Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and...

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Main Authors: Pfeiffenberger, Jan (Author) , Hornuß, Daniel (Author) , Houben, Philipp (Author) , Wehling, Cyrill (Author) , Haken, Rebecca von (Author) , Mieth, Markus (Author) , Mehrabi, Arianeb (Author) , Weiss, Karl Heinz (Author) , Friedrich, Kilian (Author)
Format: Article (Journal)
Language:English
Published: 29 July 2019
In: Journal of gastrointestinal and liver diseases
Year: 2019, Volume: 28, Issue: 3, Pages: 271-277
ISSN:1842-1121
DOI:10.15403/jgld-218
Online Access:Verlag, Volltext: https://doi.org/10.15403/jgld-218
Verlag: https://www.jgld.ro/jgld/index.php/jgld/article/view/218
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Author Notes:Jan Pfeiffenberger, Daniel Hornuss, Philip Houben, Cyrill Wehling, Rebecca von Haken, Vladimir Loszanowski, Markus Mieth, Arianeb Mehrabi, Karl-Heinz Weiss, Kilian Friedrich
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Summary:Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. - Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. - Results: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 - 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051-1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001-1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986-0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070-0.895; p=0.033). - Conclusion: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients.
Item Description:Gesehen am 31.10.2019
Physical Description:Online Resource
ISSN:1842-1121
DOI:10.15403/jgld-218

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