Routine liver elastography could predict actuarial survival after liver transplantation
Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. - Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 July 2019
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| In: |
Journal of gastrointestinal and liver diseases
Year: 2019, Volume: 28, Issue: 3, Pages: 271-277 |
| ISSN: | 1842-1121 |
| DOI: | 10.15403/jgld-218 |
| Online Access: | Verlag, Volltext: https://doi.org/10.15403/jgld-218 Verlag: https://www.jgld.ro/jgld/index.php/jgld/article/view/218 
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| Author Notes: | Jan Pfeiffenberger, Daniel Hornuss, Philip Houben, Cyrill Wehling, Rebecca von Haken, Vladimir Loszanowski, Markus Mieth, Arianeb Mehrabi, Karl-Heinz Weiss, Kilian Friedrich |
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| 520 | |a Background & Aims: Transient elastography (TE) has routinely been implemented in the diagnosis and assessment of chronic liver disease. Little data are available in the post liver transplant (LTx) setting. - Methods: Three months after LTx, we performed TE in 137 liver transplant recipients and investigated its predictive value upon further clinical outcome. The mean follow-up time for clinical outcome was 24 months. - Results: Mean TE value was 10.6 kPa (± 6.3 kPa; range 2.8 - 29.9 kPa). There was a significant correlation between TE and aspartate aminotransferase (AST) (p=0.004), gamma-glutamyl transferase (GGT) (p=0.031) and bilirubin (p<0.001) serum levels. In Cox univariate analysis, TE served as a predictor of actuarial survival free of liver transplantation (OR=1.111, 95%CI: 1.051-1.174; p<0.001). In multivariate analysis, TE remained an independent risk factor associated with reduced actuarial survival free of liver transplantation (OR=1.080, 95%CI: 1.001-1.166; p=0.047), along with thrombocytes (OR=0.992, 95%CI: 0.986-0.999; p=0.020) and metabolic co-disease (OR = 0.250, 95%CI: 0.070-0.895; p=0.033). - Conclusion: Transient elastography measurement at three months after LTx seems a robust predictor of survival in liver transplant recipients. | ||
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