The PHD1 oxygen sensor in health and disease
The hypoxia-inducible factor (HIF) co-ordinates the adaptive transcriptional response to hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred by a family of oxygen-sensing enzymes termed HIF hydroxylases. This family consists of three prolyl hydroxylases (PHD1-3) and a single aspar...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 February 2018
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| In: |
The journal of physiology
Year: 2018, Volume: 596, Issue: 17, Pages: 3899-3913 |
| ISSN: | 1469-7793 |
| DOI: | 10.1113/JP275327 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1113/JP275327 Verlag, Volltext: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP275327 
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| Author Notes: | Kilian B. Kennel, Julius Burmeister, Martin Schneider and Cormac T. Taylor |
| Summary: | The hypoxia-inducible factor (HIF) co-ordinates the adaptive transcriptional response to hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred by a family of oxygen-sensing enzymes termed HIF hydroxylases. This family consists of three prolyl hydroxylases (PHD1-3) and a single asparagine hydroxylase termed factor inhibiting HIF (FIH). It has recently become clear that HIF hydroxylases are functionally non-redundant and have discrete but overlapping physiological roles. Furthermore, altered abundance or activity of these enzymes is associated with a number of pathologies. Pharmacological HIF-hydroxylase inhibitors have recently proven to be both tolerated and therapeutically effective in patients. In this review, we focus on the physiology, pathophysiology and therapeutic potential of the PHD1 isoform, which has recently been implicated in diseases including inflammatory bowel disease, ischaemia and cancer. |
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| Item Description: | Gesehen am 31.10.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1469-7793 |
| DOI: | 10.1113/JP275327 |