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Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis

Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractur...

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Main Authors: Stahl, Mirjam (Author) , Holfelder, Christian (Author) , Kneppo, Carolin (Author) , Kieser, Meinhard (Author) , Kasperk, Christian (Author) , Schönau, Eckhard (Author) , Sommerburg, Olaf (Author) , Tönshoff, Burkhard (Author)
Format: Article (Journal)
Language:English
Published: [January 2018]
In: Journal of cystic fibrosis
Year: 2018, Volume: 17, Issue: 1, Pages: 114-120
ISSN:1873-5010
DOI:10.1016/j.jcf.2016.06.004
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.jcf.2016.06.004
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1569199316305471
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Author Notes:Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff
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Summary:Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. - Results - The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). - Conclusions - Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.
Item Description:Gesehen am 04.11.2019
Physical Description:Online Resource
ISSN:1873-5010
DOI:10.1016/j.jcf.2016.06.004

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