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Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis

Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractur...

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Hauptverfasser: Stahl, Mirjam (VerfasserIn) , Holfelder, Christian (VerfasserIn) , Kneppo, Carolin (VerfasserIn) , Kieser, Meinhard (VerfasserIn) , Kasperk, Christian (VerfasserIn) , Schönau, Eckhard (VerfasserIn) , Sommerburg, Olaf (VerfasserIn) , Tönshoff, Burkhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [January 2018]
In: Journal of cystic fibrosis
Year: 2018, Jahrgang: 17, Heft: 1, Pages: 114-120
ISSN:1873-5010
DOI:10.1016/j.jcf.2016.06.004
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.jcf.2016.06.004
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1569199316305471
Volltext
Verfasserangaben:Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff
Beschreibung
Zusammenfassung:Background - The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. - Methods - In a cross-sectional study of 43 CF patients (age, 17.8±6.2years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. - Results - The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25years was reduced to 39.8% compared to 84.6% in controls (P<0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). - Conclusions - Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.
Beschreibung:Gesehen am 04.11.2019
Beschreibung:Online Resource
ISSN:1873-5010
DOI:10.1016/j.jcf.2016.06.004

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