MEST mediates the impact of prenatal bisphenol A exposure on long-term body weight development

Exposure to endocrine-disrupting chemicals can alter normal physiology and increase susceptibility to non-communicable diseases like obesity. Especially the prenatal and early postnatal period is highly vulnerable to adverse effects by environmental exposure, promoting developmental reprogramming by...

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Main Authors: Junge, Kristin M. (Author) , Leppert, Beate (Author) , Jahreis, Susanne (Author) , Wissenbach, Dirk K. (Author) , Feltens, Ralph (Author) , Grützmann, Konrad (Author) , Thürmann, Loreen (Author) , Bauer, Tobias (Author) , Ishaque, Naveed (Author) , Schick, Matthias (Author) , Bewerunge-Hudler, Melanie (Author) , Röder, Stefan (Author) , Bauer, Mario (Author) , Schulz, Angela (Author) , Borte, Michael (Author) , Landgraf, Kathrin (Author) , Körner, Antje (Author) , Kiess, Wieland (Author) , Bergen, Martin von (Author) , Stangl, Gabriele I. (Author) , Trump, Saskia (Author) , Eils, Roland (Author) , Polte, Tobias (Author) , Lehmann, Irina (Author)
Format: Article (Journal)
Language:English
Published: 20 April 2018
In: Clinical epigenetics
Year: 2018, Volume: 10, Issue: 1
ISSN:1868-7083
DOI:10.1186/s13148-018-0478-z
Online Access:Verlag, Volltext: https://doi.org/10.1186/s13148-018-0478-z
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Author Notes:Kristin M. Junge, Beate Leppert, Susanne Jahreis, Dirk K. Wissenbach, Ralph Feltens, Konrad Grützmann, Loreen Thürmann, Tobias Bauer, Naveed Ishaque, Matthias Schick, Melanie Bewerunge-Hudler, Stefan Röder, Mario Bauer, Angela Schulz, Michael Borte, Kathrin Landgraf, Antje Körner, Wieland Kiess, Martin von Bergen, Gabriele I. Stangl, Saskia Trump, Roland Eils, Tobias Polte and Irina Lehmann
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Summary:Exposure to endocrine-disrupting chemicals can alter normal physiology and increase susceptibility to non-communicable diseases like obesity. Especially the prenatal and early postnatal period is highly vulnerable to adverse effects by environmental exposure, promoting developmental reprogramming by epigenetic alterations. To obtain a deeper insight into the role of prenatal bisphenol A (BPA) exposure in children’s overweight development, we combine epidemiological data with experimental models and BPA-dependent DNA methylation changes.
Item Description:Gesehen am 07.11.2019
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-018-0478-z