Benzaldehyde- and nickel-catalyzed photoredox C(sp3)-H alkylation/arylation with amides and thioethers
Herein a synergistic combination of a nickel catalyst and benzaldehyde for the utilization of amides and thioethers in C(sp3)-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a simple and cheap strategy for the direct functionalization of...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2, 2019
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| In: |
Organic letters
Year: 2019, Volume: 21, Issue: 16, Pages: 6329-6332 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b02226 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1021/acs.orglett.9b02226 Verlag: https://pubs.acs.org/doi/10.1021/acs.orglett.9b02226 
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| Author Notes: | Xiaojia Si, Lumin Zhang, and A. Stephen K. Hashmi |
| Summary: | Herein a synergistic combination of a nickel catalyst and benzaldehyde for the utilization of amides and thioethers in C(sp3)-H alkylation and arylation reactions employing simple aryl or alkyl halides is reported. This method provides a simple and cheap strategy for the direct functionalization of amides and thioethers. Readily available starting materials, mild reaction conditions, a good functional-group tolerance, and a broad substrate scope make this methodology attractive and practical for pharmaceutical and synthetic chemistry. |
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| Item Description: | Gesehen am 12.11.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b02226 |