Synthesis of 2-aminoindoles through gold-catalyzed C-H annulations of sulfilimines with N-arylynamides
A new gold-catalyzed C-H annulation of sulfilimines with N-phenylynamides is presented. As key intermediates of this operationally simple reaction, the in situ generated α-imino gold carbenes insert into the ortho C-H bonds of the phenyl groups to afford 2-aminoindoles bearing a variety of substitut...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 22, 2019
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| In: |
Organic letters
Year: 2019, Volume: 21, Issue: 11, Pages: 4327-4330 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b01501 |
| Online Access: | Resolving-System, Volltext: https://doi.org/10.1021/acs.orglett.9b01501 Verlag: https://pubs.acs.org/doi/10.1021/acs.orglett.9b01501 
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| Author Notes: | Xianhai Tian, Lina Song, Matthias Rudolph, Frank Rominger, and A. Stephen K. Hashmi |
| Summary: | A new gold-catalyzed C-H annulation of sulfilimines with N-phenylynamides is presented. As key intermediates of this operationally simple reaction, the in situ generated α-imino gold carbenes insert into the ortho C-H bonds of the phenyl groups to afford 2-aminoindoles bearing a variety of substitution patterns in high selectivities. This reaction offers a facile approach to biologically important 2-aminoindoles by using inexpensive and readily available starting materials. |
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| Item Description: | Gesehen am 12.11.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.9b01501 |